Various Citrus

DIOSMIN

CAS No.: 520-27-4

EIENCS No.: 208-289-7

Molecular Formula: C28H32O15

Molecular Weight: 608.545

Specification: EP, BP, USP, 90:10 Micronized

Description

Diosmin is a semisynthetic flavonoid molecule derived from citrus d(modified hesperidin). Diosmin is used for treating various disorders of blood vessels including hemorrhoids, varicose veins, poor circulation in the leg(venous stasis), and bleeding(hemorrhage) in the eye or gums. It is also used to treat swelling of the arms(lymphedema) following breast cancer surgery, and to protect against liver toxicity. It is often taken in combination with hesperidin. Diosmin is currently a prescription medication in some European countries, and is sold as a nutritional supplement in the US.

diosmin

SPECIFICATION SHEET

Product NameDiosmin
Botanical SourceCitrus Aurantium L.
Used PartImmature fruit
CodeBPBE-610-A
SpecificationEP8.3 Micronized
AppearanceGreyish-yellow or light yellow, hygroscopic powder
SolubilityPractically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in ethanol (96%), it dissolves in dilute solution of alkali hydroxides
IdentificationA)IR: Complies diosmin CRS; B)HPLC: Complies to the reference solution
Iodine≤0.1%
Related Substances 
Impurity A(Acetoisovanillone)≤0.5%
Impurity B(Hesperidin)≤4.0%
Impurity C(Isorhoifolin)≤3.0%
Impurity D(6-iododiosmin)≤0.6%
Impurity E (Linarin)≤3.0%
Impurity F(Diosmetin)≤2.0%
Unspecified Impurities(each)≤0.4%
Total Impurities≤8.5%
Heavy Metals≤20ppm
Water≤6.0%
Sulphated Ash≤0.2%
Particle SizeNLT90% below 5 microns
Assay(HPLC, Anhydrous substance)90.0%~102.0%
Residual Solvents 
Methanol≤3000ppm
Ethanol≤5000ppm
Pyridine≤200ppm
Total Plate Count≤1000cfu/g
-Yeast & Mold≤100cfu/g
-E.ColiNegative
-SalmonellaNegative
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